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WNT11
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Post-translational modifications
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
Sequence similarities
Belongs to the Wnt family.
Tissue specificity
Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
- Protein Wnt-11
- WNT11
Database links
Target type
Proteins
Primary research area
Oncology
Molecular weight
39179Da