WNT16

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Post-translational modifications

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Sequence similarities

Belongs to the Wnt family.

Tissue specificity

Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix

Alternative names

• Protein Wnt-16
• WNT16

Database links

• entrezGene:51384
• omim:606267
• swissprot:Q9UBV4

Target type

Proteins

Molecular weight

40690Da