WNT16

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Belongs to the Wnt family.

Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas.

• Secreted
• Extracellular space
• Extracellular matrix

Protein Wnt-16, WNT16

• entrezGene:51384
• omim:606267
• swissprot:Q9UBV4

Proteins

Oncology

40690Da