WNT8A
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.
Post-translational modifications
Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.
Sequence Similarities
Belongs to the Wnt family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
Alternative names
WNT8D, WNT8A, Protein Wnt-8a, Protein Wnt-8d