WNT9B
Function
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity).
Post-translational modifications
Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
Sequence Similarities
Belongs to the Wnt family.
Tissue Specificity
Moderately expressed in fetal kidney and adult kidney. Also found in brain.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Secreted
Alternative names
WNT14B, WNT15, UNQ6973/PRO21956, WNT9B, Protein Wnt-9b, Protein Wnt-14b, Protein Wnt-15