WRNIP1
Domain
The UBZ4-type zinc finger binds ubiquitin.
Function
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS.
Post-translational modifications
Sumoylated with SUMO1 and SUMO2/3.
Sequence Similarities
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Nucleus
- Cytoplasm
- Colocalizes with WRN in granular structures in the nucleus.
Alternative names
WHIP, WRNIP1, ATPase WRNIP1, Werner helicase-interacting protein 1