WWC2
Function
Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway.
Sequence Similarities
Belongs to the WWC family.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
BOMB, WWC2, Protein WWC2, BH-3-only member B, WW domain-containing protein 2