XCL1
Function
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Sequence Similarities
Belongs to the intercrine gamma family.
Tissue Specificity
Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Cellular localization
- Secreted
Alternative names
LTN, SCYC1, XCL1, Lymphotactin, ATAC, C motif chemokine 1, Cytokine SCM-1, Lymphotaxin, SCM-1-alpha, Small-inducible cytokine C1, XC chemokine ligand 1