Xdh
Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
Post-translational modifications
Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).
Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).
Sequence Similarities
Belongs to the xanthine dehydrogenase family.
Cellular localization
- Cytoplasm
- Peroxisome
- Secreted
Alternative names
Xanthine dehydrogenase/oxidase, Xdh