XPNPEP1
Function
Metalloaminopeptidase that catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (PubMed:11106490, PubMed:18515364, PubMed:35165443). Contributes to the degradation of bradykinin (PubMed:11106490).
Sequence Similarities
Belongs to the peptidase M24B family.
Tissue Specificity
Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas.
Cellular localization
- Cytoplasm
- Cytosol
Alternative names
XPNPEPL, XPNPEPL1, XPNPEP1, Xaa-Pro aminopeptidase 1, Aminoacylproline aminopeptidase, Cytosolic aminopeptidase P, Soluble aminopeptidase P, X-Pro aminopeptidase 1, sAmp