XPNPEP2
Function
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.
Involvement in disease
Angioedema induced by ACE inhibitors
AEACEI
A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the peptidase M24B family.
Tissue Specificity
Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Xaa-Pro aminopeptidase 2, Aminoacylproline aminopeptidase, Membrane-bound aminopeptidase P, X-Pro aminopeptidase 2, Membrane-bound APP, Membrane-bound AmP, mAmP, XPNPEP2