XRN1
Function
Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).
Sequence Similarities
Belongs to the 5'-3' exonuclease family.
Tissue Specificity
Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines.
Cellular localization
- Cytoplasm
- Discrete foci at the inner surface of the cell membrane.
Alternative names
SEP1, XRN1, 5'-3' exoribonuclease 1, Strand-exchange protein 1 homolog