YIPF3
Developmental stage
Expressed in fetal liver (at protein level). Expressed in embryonic hematopoiesis sites.
Function
Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
Post-translational modifications
N-glycosylated in the ER (40 kDa form I), then O-glycosylated in the Golgi apparatus (46 kDa form II), the C-terminal lumenal region is later removed in the Golgi apparatus to produce a 36 kDa form III. O-glycosylated with core 1-like and core 2-like glycans. O-glycan heterogeneity at Thr-346: HexNAc (minor), HexHexNAc (major), Hex1HexNAc2 (minor), Hex2HexNAc2 (minor) and dHex1Hex2HexNAc2 (minor).
Sequence Similarities
Belongs to the YIP1 family.
Tissue Specificity
Expressed by nucleated hematopoietic cells (at protein level).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
- Golgi apparatus
- cis-Golgi network membrane
- Multi-pass membrane protein
- Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.
Alternative names
C6orf109, KLIP1, YIPF3, Protein YIPF3, Killer lineage protein 1, Natural killer cell-specific antigen KLIP1, YIP1 family member 3