YWHAE

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448).

Post-translational modifications

(Microbial infection) Cleaved by poliovirus protease 3C, leading to disruption of the interaction with RIGI.

Sequence similarities

Belongs to the 14-3-3 family.

Cellular localization

• Nucleus
• Cytoplasm
• Melanosome
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Alternative names

• 14-3-3 protein epsilon
• 14-3-3E
• YWHAE

Database links

• entrezGene:7531
• omim:605066
• swissprot:P62258

Target type

Proteins

Molecular weight

29174Da