YWHAH
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Post-translational modifications
Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
Sequence Similarities
Belongs to the 14-3-3 family.
Tissue Specificity
Expressed mainly in the brain and present in other tissues albeit at lower levels.
Alternative names
YWHA1, YWHAH, 14-3-3 protein eta, Protein AS1