YWHAQ

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Post-translational modifications

Ser-232 is probably phosphorylated by CK1.

Sequence similarities

Belongs to the 14-3-3 family.

Tissue specificity

Abundantly expressed in brain, heart and pancreas, and at lower levels in kidney and placenta. Up-regulated in the lumbar spinal cord from patients with sporadic amyotrophic lateral sclerosis (ALS) compared with controls, with highest levels of expression in individuals with predominant lower motor neuron involvement.

Cellular localization

• Cytoplasm
• In neurons, axonally transported to the nerve terminals.

Alternative names

• 14-3-3 protein theta
• 14-3-3 protein T-cell
• 14-3-3 protein tau
• Protein HS1
• YWHAQ

Database links

• entrezGene:10971
• omim:609009
• swissprot:P27348

Target type

Proteins

Molecular weight

27764Da