ZAN
Domain
The MAM domains probably mediate sperm adhesion to the zona pellucida.
During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
The VWFD domain 2 may mediate covalent oligomerization.
Function
Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.
Tissue Specificity
In testis, primarily in haploid spermatids.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Exclusively on the apical region of the sperm head.
Alternative names
Zonadhesin, ZAN