ZBED1
Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12 (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747). The resulting increased transcriptional activity drives cell proliferation (PubMed:12663651, PubMed:17220279). Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins (PubMed:12663651, PubMed:17209048, PubMed:17220279, PubMed:27068747).
(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Pathway
Protein modification; protein sumoylation.
Post-translational modifications
Autosumoylated with SUMO1, SUMO2, and SUMO3.
Tissue Specificity
Ubiquitously expressed at low levels (PubMed:9887332). Expression is highest in skeletal muscle, heart, spleen and placenta (PubMed:9887332).
Cellular localization
- Nucleus
- PML body
- Nucleus
- In granular structures.
- Nucleus
- PML body
- (Microbial infection) Upon interaction with human adenovirus early E1A protein, the protein is redistributed to the peripheral areas of PML bodies.
Alternative names
ALTE, DREF, hDREF, KIAA0785, TRAMP, ZBED1, E3 SUMO-protein ligase ZBED1, DNA replication-related element-binding factor, Putative Ac-like transposable element, Zinc finger BED domain-containing protein 1, dREF homolog