ZBED3
Function
Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin (By similarity). Involved in transcription activation of Wnt target gene expression (By similarity). Plays a role in symmetric division of blastomeres in the early stages of embryogenesis via regulation of mitotic spindle central positioning and organization of the F-actin filament network (By similarity). Plays a role in regulating the distribution of cellular organelles, via modulation of cytoskeletal dynamics and cytoplasmic lattice formation (By similarity).
Tissue Specificity
Secreted in blood plasma, and expressed in skeletal muscle and adipose tissue (at protein level).
Cellular localization
- Cytoplasm
- Membrane
- Secreted
Alternative names
Zinc finger BED domain-containing protein 3, Axin-interacting protein, ZBED3