ZBTB33
Function
Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1 (PubMed:23251453).
Tissue Specificity
Expressed in vascular endothelium.
Cellular localization
- Nucleus
- Cytoplasm
- Also cytoplasmic in cells grown at high densities.
Alternative names
KAISO, ZNF348, ZBTB33, Transcriptional regulator Kaiso, Zinc finger and BTB domain-containing protein 33