ZC3H12D
Function
May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).
Involvement in disease
A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.
Sequence Similarities
Belongs to the ZC3H12 family.
Tissue Specificity
Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.
Cellular localization
- Cytoplasm
- P-body
- Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).
- Isoform 1
- Cytoplasm
- Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.
- Isoform 3
- Cytoplasm
- Nucleus
Alternative names
C6orf95, MCPIP4, TFL, ZC3H12D, Probable ribonuclease ZC3H12D, MCP-induced protein 4, Transformed follicular lymphoma, Zinc finger CCCH domain-containing protein 12D, p34