ZC3H12D

May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).

A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.

Belongs to the ZC3H12 family.

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.

• Cytoplasm
• P-body
• Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).
• Isoform 1
• Cytoplasm
• Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.
• Isoform 3
• Cytoplasm
• Nucleus

C6orf95, MCPIP4, TFL, ZC3H12D, Probable ribonuclease ZC3H12D, MCP-induced protein 4, Transformed follicular lymphoma, Zinc finger CCCH domain-containing protein 12D, p34

• entrezGene:340152
• omim:611106
• swissprot:A2A288

Proteins

58078Da