ZC3H14
Function
Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.
Involvement in disease
Intellectual developmental disorder, autosomal recessive 56
MRT56
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the ZC3H14 family.
Tissue Specificity
Isoform 1 and isoform 6 are expressed in fetal and adult brain. Isoform 1 and isoform 6 are expressed in fetal and adult temporal lobe.
Cellular localization
- Nucleus speckle
- Colocalizes with poly(A) RNA in nuclear speckles.
- Isoform 1
- Nucleus speckle
- Isoform 3
- Nucleus speckle
- Isoform 6
- Cytoplasm
Alternative names
Zinc finger CCCH domain-containing protein 14, Mammalian suppressor of tau pathology-2, Renal carcinoma antigen NY-REN-37, MSUT-2, ZC3H14