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ZCWPW2

Domain

The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.

Function

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).

Alternative names

Zinc finger CW-type PWWP domain protein 2, ZCWPW2

swissprot:Q504Y3 entrezGene:152098