ZDHHC12
Domain
The DHHC domain is required for palmitoyltransferase activity.
Function
Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:36586411). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process (PubMed:36586411).
Sequence Similarities
Belongs to the DHHC palmitoyltransferase family.
Tissue Specificity
Widely expressed.
Cellular localization
- Golgi apparatus membrane
- Multi-pass membrane protein
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
ZNF400, PSEC0008, ZDHHC12, Palmitoyltransferase ZDHHC12, DHHC domain-containing cysteine-rich protein 12, Zinc finger DHHC domain-containing protein 12, Zinc finger protein 400, DHHC-12