ZFAND6

Domain

The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.

The AN1-type zinc finger domain mediates association with TRAF2.

Function

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Tissue Specificity

Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.

Cellular localization

• Cytoplasm

Alternative names

AWP1, ZA20D3, HT032, ZFAND6, AN1-type zinc finger protein 6, Associated with PRK1 protein, Zinc finger A20 domain-containing protein 3

Database links

swissprot:Q6FIF0 omim:610183 swissprot:Q9BQF7 entrezGene:54469