ZFAND6

The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.

The AN1-type zinc finger domain mediates association with TRAF2.

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.

• Cytoplasm

AWP1, ZA20D3, HT032, ZFAND6, AN1-type zinc finger protein 6, Associated with PRK1 protein, Zinc finger A20 domain-containing protein 3

• entrezGene:54469
• omim:610183
• swissprot:Q6FIF0
• swissprot:Q9BQF7

Proteins

Epigenetics

22555Da