ZFYVE9
Domain
The SMAD binding domain (SBD) interacts with the MH2 domains of SMAD2 or SMAD3.
The FYVE-type zinc finger is necessary and sufficient for its localization into early endosomes and mediates the association with PI3P.
Function
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Tissue Specificity
Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
Cellular localization
- Cytoplasm
- Early endosome membrane
Alternative names
MADHIP, SARA, SMADIP, ZFYVE9, Zinc finger FYVE domain-containing protein 9, Mothers against decapentaplegic homolog-interacting protein, Novel serine protease, Receptor activation anchor, Smad anchor for receptor activation, Madh-interacting protein, NSP, hSARA