ZHX2
Function
Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).
Sequence Similarities
Belongs to the ZHX family.
Tissue Specificity
Ubiquitously expressed. Expressed in podocytes.
Cellular localization
- Nucleus
- Colocalizes with EFNB1 intracellular domain in the nucleus.
Alternative names
AFR1, KIAA0854, RAF, ZHX2, Zinc fingers and homeoboxes protein 2, Alpha-fetoprotein regulator 1, Regulator of AFP, Zinc finger and homeodomain protein 2, AFP regulator 1