ZHX2

Acts as a transcriptional repressor (PubMed:12741956). Represses the promoter activity of the CDC25C gene stimulated by NFYA (PubMed:12741956). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells (By similarity). In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex (By similarity).

Belongs to the ZHX family.

Ubiquitously expressed. Expressed in podocytes.

• Nucleus
• Colocalizes with EFNB1 intracellular domain in the nucleus.

AFR1, KIAA0854, RAF, ZHX2, Zinc fingers and homeoboxes protein 2, Alpha-fetoprotein regulator 1, Regulator of AFP, Zinc finger and homeodomain protein 2, AFP regulator 1

• entrezGene:22882
• omim:609185
• swissprot:Q9Y6X8

Proteins

Oncology

92307Da