Zinc finger protein GLIS1
Function
Acts both as a repressor and an activator of transcription (PubMed:21654807). Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells (PubMed:21654807). Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast (By similarity).
Sequence Similarities
Belongs to the GLI C2H2-type zinc-finger protein family.
Cellular localization
- Nucleus
Alternative names
Zinc finger protein GLIS1, GLI-similar 1, GLIS1