ZNF24
Function
Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence (By similarity). Has transcription repressor activity in vitro.
Post-translational modifications
Sumoylated.
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Tissue Specificity
Expressed in many tissues except in heart.
Cellular localization
- Nucleus
Alternative names
KOX17, ZNF191, ZSCAN3, ZNF24, Zinc finger protein 24, Retinoic acid suppression protein A, Zinc finger and SCAN domain-containing protein 3, Zinc finger protein 191, Zinc finger protein KOX17, RSG-A