May play a role in uric acid excretion.
Uric acid nephrolithiasis
UAN
A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Isoform 4 is expressed in placenta, lung, kidney and pancreas.
KIAA0844, ZNF365, Talanin
Proteins
Oncology
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