ZNF593
Domain
The protein is largely disordered, with the exception of the zinc finger domain.
Function
Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome (PubMed:32669547). Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity (PubMed:9115366).
Sequence Similarities
Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.
Tissue Specificity
Ubiquitous. Detected in spleen, prostate, testis, small intestine, colon and to a minor level in thymus and peripheral blood leukocytes.
Cellular localization
- Nucleus
- Nucleolus
- Cytoplasm
- Shuttles between the nucleus and the cytoplasm.
Alternative names
ZT86, ZNF593, Zinc finger protein 593, Zinc finger protein T86