ZNF703
Function
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
Involvement in disease
Luminal B breast cancers are the clinically more aggressive estrogen receptor-positive tumors. Amplification of a distal 8p12 locus occurs in around one third of the cases and ZNF703 is the single gene within the minimal amplicon. Amplification of the gene correlates with its protein expression in tumor cells. ZNF703 is a classical breast cancer oncogene since it is able to transform non-malignant cells and increase cellular proliferation.
Sequence Similarities
Belongs to the Elbow/Noc family.
Tissue Specificity
Expressed in mammary epithelium.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
ZEPPO1, ZPO1, ZNF703, Zinc finger protein 703, Zinc finger elbow-related proline domain protein 1