ZNF746
Function
Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
Post-translational modifications
Ubiquitinated by PRKN. 'Lys-48'-linked polyubiquitination by PRKN leads to degradation by the proteasome and may play a key role in regulation of neuron death.
Sequence Similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Cellular localization
- Cytoplasm
- Nucleus
- Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Alternative names
PARIS, ZNF746, Zinc finger protein 746, Parkin-interacting substrate