ZNRF3
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the ZNRF3 family.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
KIAA1133, RNF203, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3