ZNRF3

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity).

Protein modification; protein ubiquitination.

Belongs to the ZNRF3 family.

• Cell membrane
• Single-pass type I membrane protein

KIAA1133, RNF203, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3

• swissprot:Q9ULT6

Proteins

14154Da