ZP1
Domain
The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
Function
Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.
Involvement in disease
Oocyte/zygote/embryo maturation arrest 1
OZEMA1
An autosomal recessive infertility disorder caused by defective oocyte maturation that results in abnormal eggs lacking a zona pellucida. Affected females have normal menstrual cycles and sex hormone levels, no obstruction in the fallopian tubes or abnormalities of the uterus or adnexa.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
O-glycosylated.
Sequence Similarities
Belongs to the ZP domain family. ZPB subfamily.
Tissue Specificity
Expressed in oocytes (at protein level).
Cellular localization
- Processed zona pellucida sperm-binding protein 1
- Zona pellucida
- Cell membrane
- Single-pass type I membrane protein
Alternative names
Zona pellucida sperm-binding protein 1, Zona pellucida glycoprotein 1, Zp-1, ZP1