ZP2

The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).

Oocyte/zygote/embryo maturation arrest 6

OZEMA6

An autosomal recessive infertility disorder characterized by oocyte fertilization failure, due to defective sperm-binding to an abnormally thin zona pellucida in patient oocytes.

None

The disease is caused by variants affecting the gene represented in this entry.

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.

Proteolytically cleaved in the N-terminal part by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy. Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos.

N-glycosylated.

O-glycosylated; contains sulfate-substituted glycans.

Belongs to the ZP domain family. ZPA subfamily.

Expressed in occytes(at protein level).

• Processed zona pellucida sperm-binding protein 2
• Zona pellucida
• Cell membrane
• Single-pass type I membrane protein

ZPA, ZP2, Zona pellucida sperm-binding protein 2, Zona pellucida glycoprotein 2, Zona pellucida protein A, Zp-2

• entrezGene:7783
• omim:182888
• swissprot:Q05996

Proteins

Developmental Biology

82357Da