ZPBP

Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).

Spermatogenic failure 66

SPGF66

An autosomal recessive male infertility disorder characterized by globozoospermia. Affected individuals have a normal sperm count, but spermatozoa are round-headed and lack the acrosome. In addition to pure globozoospermia, some patients have a mixture of acrosomeless spermatozoa and spermatozoa with small or detached acrosomes, which is defined as acrosomal hypoplasia.

None

The disease may be caused by variants affecting the gene represented in this entry.

N-glycosylated.

Belongs to the zona pellucida-binding protein Sp38 family.

Expressed specifically in testis.

• Cytoplasmic vesicle
• Secretory vesicle
• Acrosome
• Cytoplasmic vesicle
• Secretory vesicle
• Acrosome membrane
• Peripheral membrane protein
• Secreted
• First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.

ZPBP1, ZPBP, Zona pellucida-binding protein 1, Inner acrosomal membrane IAM38, Sp38

• entrezGene:11055
• omim:608498
• swissprot:Q9BS86

Proteins

40142Da