ZPBP
Function
Plays a role in acrosome compaction and sperm morphogenesis (PubMed:21911476). Is implicated in sperm-oocyte interaction during fertilization (By similarity).
Involvement in disease
Spermatogenic failure 66
SPGF66
An autosomal recessive male infertility disorder characterized by globozoospermia. Affected individuals have a normal sperm count, but spermatozoa are round-headed and lack the acrosome. In addition to pure globozoospermia, some patients have a mixture of acrosomeless spermatozoa and spermatozoa with small or detached acrosomes, which is defined as acrosomal hypoplasia.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the zona pellucida-binding protein Sp38 family.
Tissue Specificity
Expressed specifically in testis.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome membrane
- Peripheral membrane protein
- Secreted
- First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction.
Alternative names
ZPBP1, ZPBP, Zona pellucida-binding protein 1, Inner acrosomal membrane IAM38, Sp38