ZSCAN4
Function
Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).
Cellular localization
- Nucleus
- Chromosome
- Telomere
Alternative names
ZNF494, ZSCAN4, Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494