ZWILCH
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131).
Sequence Similarities
Belongs to the ZWILCH family.
Cellular localization
- Chromosome
- Centromere
- Kinetochore
Alternative names
Protein zwilch homolog, hZwilch, ZWILCH