Quick reference guide to histone modifications
A cheat sheet for the most common histone modifications and where to find them.
A cheat sheet for the most common histone modifications and where to find them:
Histone modification
Function
Location
H3K4me1
Activation
Enhancers
H3K4me3
Activation
Promoters, bivalent domains
H3K36me3
Activation
Gene bodies
H3K79me2
Activation
Gene bodies
H3K9Ac
Activation
Enhancers, promoters
H3K27Ac
Activation
Enhancers, promoters
H4K16Ac
Activation
Repetitive sequences
H3K27me3
Repression
Promoters in gene-rich regions, developmental regulators, bivalent domains
H3K9me3
Repression
Satellite repeats, telomeres, pericentromeres
Gamma H2A.X
DNA damage
DNA double-strand breaks
H3S10P
DNA replication
Mitotic chromosomes