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Autophagy in heart disease pathway

This poster explores the contribution of autophagy to the development of heart disease.
Last edited Thu 22 Feb 2024

Autophagy is a fundamental cellular process that entails the breakdown and recycling of defective components within the cell and is crucial for maintaining cellular equilibrium. This self-contained mechanism selectively eliminates misfolded proteins and worn-out organelles.

While autophagy protects the heart from myocardial ischemic damage and the subsequent related ischemic processes, it can exacerbate harm due to ischemic/reperfusion injury and coronary atherosclerosis. Therefore, targeting specific components of the autophagic signaling pathways activated in pathological cardiac conditions may hold promise for mitigating the resultant damage.

Autophagy in heart disease poster