Chemokine signaling pathway
This pathway highlights the different classes of chemokines, their receptors, and how chemokine signaling activates the JAK/Stat, Ras, ERK, and Akt pathways.
Chemokines are a family of small cytokines (~8 kDa) whose primary function is to attract immune system cells at sites of inflammation. Chemokines are classified into four groups based on their cysteine residues pattern: CXC (α chemokines), CC (β chemokines), CX3C and C.
Chemokine receptors are class A GPCRs; however, not all receptors are selective for a single ligand. A chemokine may bind several receptors and exhibit agonist behavior with some and antagonist behavior with others. Some commonly activated downstream pathways include JAK/Stat, Ras, Erk, and Akt.