Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS. It acts through ligand gated ion channels (ionotropic receptors) and G-protein coupled (metabotropic) receptors. These receptors are involved in excitatory synaptic transmission and synaptic plasticity which are thought to underlie learning and memory. Glutamate uptake in the CNS is mediated by high-affinity, sodium-dependent excitatory amino acid transporters (EAAT1-5).
Chen et al. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. BJP 147:839-853 (2006). Read more (PubMed: 16474411) »
Collingridge et al. A nomenclature for ligand-gated ion channels. Neuropharmacology 56:2-5 (2009). Read more (PubMed: 18655795) »
Kew JN et al. Ionotropic and metabotropic glutamate receptor structure and pharmacology. Psychopharmacology (Berl). 179(1):4-29 (2005). Read more (PubMed: 15731895) »
Schoepp et al. Pharmacological agents acting at subtypes of metabotropic glutamate receptor. Neuropharmacology 38:1431-1476 (1999). Read more (PubMed: 10530808) »
Trist et al. Excitatory amino acids agonists and antagonists: pharmacology and the therapeutic applications. Pharmaceutical Acta Helvetiae 74:221-229 (2000). Read more (PubMed: 10812962) »