Histone modification antibodies

Get sensitive, easy-to-interpret results every time with highly specific monoclonal antibodies to histone modifications. Recombinant monoclonal antibodies eliminate batch-to-batch variation to give you a consistent antibody and reproducible results throughout your project. 

Monoclonal antibodies specifically detect one epitope on the protein of interest. They produce more reproducible results than polyclonal antibodies and are less likely to cross-react with other proteins. It makes sense to use a monoclonal antibody binding only to the modification of interest for histone modifications to achieve a consistent, reproducible result.

Polyclonal antibodies are composed of a mixture of antibodies that represents the natural immune response to an antigen. This mixture of antibodies detects a range of epitopes on a protein and consequently, are prone to a higher risk of lot-to-lot variability than monoclonal antibodies.

Many of our histone modification antibodies are screened by peptide array to select antibodies that do not cross-react with other histone modifications. Our array covers 501 peptides, including single and multiple modifications, unmodified controls, and histone variants.

Our recombinant monoclonal histone modification antibodies are also routinely validated using several applications including:

• ChIP
• IHC/ICC
• Western blot
• Dot blot