Antibodies to RNA modifications
Unlock new areas of epigenetics with our range of antibodies to RNA modifications and their readers, writers, and erasers.
RNA modifications are out there, but so little is known about their function. That’s why our range of antibodies includes RNA modifications not covered by anyone else. This means you can take your first leap into a new, unexplored area of epigenetics. Discover novel modifications, seek out new meaning and new ideas. Boldly go where no scientist has gone before.
Find more RNA modification resources here.
Working with RNA modifications
The field of RNA modifications is relatively new but growing more and more every day. We know that working with these modifications can be tricky. That is why we are adding to our RNA modifications range all the time to get reagents for the newest and most exciting modifications before anyone else. We also know that getting antibodies truly specific to your RNA modification of choice can be difficult, so we use multiple applications to test the specificity of all our antibodies.
You can get the best reagents for your RNA modification research right here. Our m6A antibody has been cited in several significant publications, including a Nature Methods paper, which uses it for single-base resolution sequencing of m6A1. This same m6A antibody also features in a Nature paper, looking at the role of m6A in mRNA stability2. Our ac4C antibody was also published in a 2018 Cell paper, which uncovers the role of ac4C in mRNA translation efficiency3.
The benefits of using recombinant technology
Recombinant technology eliminates batch-to-batch variation by using the same immunogen for each round of antibody production. This gives you a consistent antibody andreproducible results throughout your project. Many of our RNA modification antibodies are recombinant monoclonal antibodies, including key targets such as m6A, m1A, Mettl3, m2,2G, and many more.
Browse our RNA modification antibody range
Mauer J et al. Nature, 2017
Kan L et al. Nat Commun, 2017
Vu L.P. et al. Nat Med, 2017
Sledz P et al. Elife, 2016
Linder B et al. Nat Methods, 2015
Nature 541:371-375 (2017), Nat Commun 8:15737 (2017), Nat Med 23:1369-1376 (2017), Elife 5:N/A (2016), Nat Methods 12:767-72 (2015)
References
1) Linder B et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat Methods 12:767-72 (2015).
2) Mauer J et al. Reversible methylation of m(6)Am in the 5' cap controls mRNA stability. Nature 541:371-375 (2017).
3) Arango et al. Acetylation of Cytidine in mRNA Promotes Translation Efficiency. Cell 13;175(7):1872-1886 (2018).