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Antibodies to RNA modifications
RNA modifications are out there, but so little is known about their function. That’s why our range of antibodies includes RNA modifications not covered by anyone else. This means you can take your first leap into a new, unexplored area of epigenetics. Discover novel modifications, seek out new meaning and new ideas. Boldly go where no scientist has gone before.
Working with RNA modifications
The field of RNA modifications is relatively new but growing more and more every day. We know that working with these modifications can be tricky. That is why we are adding to our RNA modifications range all the time to get reagents for the newest and most exciting modifications before anyone else. We also know that getting antibodies truly specific to your RNA modification of choice can be difficult, so we use multiple applications to test the specificity of all our antibodies.
You can get the best reagents for your RNA modification research right here. Our m6A antibody has been cited in several significant publications, including a Nature Methods paper, which uses it for single-base resolution sequencing of m6A1. This same m6A antibody also features in a Nature paper, looking at the role of m6A in mRNA stability2. Our ac4C antibody was also published in a 2018 Cell paper, which uncovers the role of ac4C in mRNA translation efficiency3.
The benefits of using recombinant technology
Recombinant technology eliminates batch-to-batch variation by using the same immunogen for each round of antibody production. This gives you a consistent antibody and reproducible results throughout your project. Many of our RNA modification antibodies are recombinant monoclonal antibodies, including key targets such as m6A, m1A, Mettl3, m2,2G, and many more.
Browse our RNA modification antibody range
Target | Function | Antibody | Key citations |
m6A | mRNA stability, splicing | Anti-N6-methyladenosine (m6A) antibody [mAbcam 190886] | Nature 537:369-373 (2016) |
Anti-N6-methyladenosine (m6A) antibody (ab151230) | Mauer J et al. Nature, 2017 Kan L et al. Nat Commun, 2017 Vu L.P. et al. Nat Med, 2017 Sledz P et al. Elife, 2016 Linder B et al. Nat Methods, 2015 Nature 541:371-375 (2017), Nat Commun 8:15737 (2017), Nat Med 23:1369-1376 (2017), Elife 5:N/A (2016), Nat Methods 12:767-72 (2015) | ||
ac4C | Translation efficiency, mRNA stability | Anti-N4-acetylcytidine (ac4C) antibody [EPRNCI-184-128] (ab252215) | Cell 175:1872-1886 (2018), ACS Chem Biol 12:2922-2926 (2017) |
m1A | Translation, tRNA stability | Anti-1-methyladenosine (m1A) antibody [EPR-19836-208] | Be the first to discover something new |
m2,2G | Unknown | Anti-N2,N2-dimethylguanosine (m2,2G) antibody [EPR-19838-40] | Be the first to discover something new |
m4C | Protection against restriction enzymes (bacteria) | Anti-N4-methylcytidine (m4C) antibody [EPR -19850-108] | Be the first to discover something new |
m2A | Unknown | Anti-2-methyladenosine (m2A) antibody [EPR -19851-59] | Be the first to discover something new |
m6,6A | Unknown | Anti-N6,N6-dimethyladenosine (m6,6A) antibody [EPR-19831-44] | Be the first to discover something new |
m8A | Unknown | Anti-8-methyladenosine (m8A) antibody [EPR-20836-125-1] | Be the first to discover something new |
YTHDF1 | m6A reader | Anti-YTHDF1 antibody [EPR22349-16] (ab252346) | Be the first to discover something new |
YTHDF1 | m6A reader | Anti-YTHDF1 antibody [EPR22349-41] (ab220162) | Be the first to discover something new |
hnRNPA2B1 | m6A reader | Anti-hnRNP A2B1 antibody [DP3B3] (ab6102) | Mol Cell Biol 37:N/A (2017), Nucleic Acids Res 45:12214-12240 (2017), Sci Rep 6:20193 (2016), PLoS Genet 9:e1003628 (2013) |
Anti-hnRNP A2B1 antibody (ab31645) | Elife 6:N/A (2017), Genome Biol 16:213 (2015), RNA Biol 11:1262-79 (2014), Nucleic Acids Res N/A:N/A (2013) | ||
hnRNP C1/C2 | m6A reader | Anti-hnRNP C1 + C2 antibody [4F4] (ab10294) | Nucleic Acids Res 45:6822-6836 (2017), RNA Biol 13:569-81 (2016), Nucleic Acids Res 44:10454-10466 (2016), Genes Dev 29:2054-66 (2015) |
Anti-hnRNP C1 + C2 antibody [EP3034Y] (ab75822) | J Virol 86:7180-91 (2012) | ||
Mettl3 | m6A writer | Anti-METTL3 antibody [EPR18810] | Mol Cell 69:1028-1038.e6 (2018), Int J Obes (Lond) N/A: N/A (2018), Biochem Biophys Res Commun N/A: N/A (2016) |
Mettl14 | m6A writer | Anti-METTL14 antibody (ab98166) | Cell Rep 14:93-102 (2016) |
WTAP | m6A writer | Anti-WTAP antibody [EPR18744] | Be the first to discover something new |
Rbm15 | m6A writer | Anti-Rbm15 antibody (ab70549) | Genes Dev 32:415-429 (2018), J Biol Chem 288:33292-302 (2013) |
NAT10 | ac4C writer | Anti-ALP antibody [EPR18663] (ab194297) | Be the first to discover something new |
ALKBH5 | m6A eraser | Anti-ALKBH5 antibody (ab69325) | Nature 541:371-375 (2017), J Biol Chem 287:29801-14 (2012) |
Anti-ALKBH5 antibody (ab174124) | Nat Immunol 18:1094-1103 (2017) | ||
FTO | m6A eraser | Anti-FTO antibody [EPR6895] | Cell 172:90-105.e23 (2018), Nature 541:371-375 (2017), Elife 5:N/A (2016), Nucleic Acids Res 43:373-84 (2015), Nature 505:117-20 (2014) |
PUS1 | Pseudouridin writer | Anti-PUS1 antibody [EPR20181] | Be the first to discover something new |
DKC1 | Pseudouridin writer | Anti-DKC1 antibody [EPR10399] | Be the first to discover something new |
m1G | tRNA stability and translational fidelity | Anti-1-methylguanosine (m1G) antibody [EPR19833-150] | Be the first to discover something new |
References
1) Linder B et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat Methods 12:767-72 (2015).
2) Mauer J et al. Reversible methylation of m(6)Am in the 5' cap controls mRNA stability. Nature 541:371-375 (2017).
3) Arango et al. Acetylation of Cytidine in mRNA Promotes Translation Efficiency. Cell 13;175(7):1872-1886 (2018).