Endothelial cell markers
Select the right endothelial cell markers based on your cell localization and application.
We've put together a list of the most widely used endothelial cell markers and their localization based on recent research. For each marker, you'll find our recommended antibodies with the applications they have been tested in - making it quicker and easier for you to choose the best tools for your experiment.
CD31
CD31 is localized in Endothelial cells, B cells, platelets, macrophages, monocytes, NK cells, T cells.
This marker has been tested in IHC-P.
We recommend
References
CD34
Localized in dendritic cells, HSCs, leukemic cells, endothelial progenitor cells, endothelial cells of blood vessels.
We recommend
References
CD45
Localized in hematopoietic cells (except mature erythrocytes).
We recommend
References
ICAM-1
Alternative names CD54
Localized in vascular endothelium, lymphocytes, macrophages.
We recommend
References
LYVE-1
Localized in lymphatic endothelial cells.
We recommend
References
Tie-2
Alternative names Tek
Localized in vascular endothelial cells.
We recommend
References
VCAM-1
Alternative names CD106
Localized in low expression on a large proportion of resting vascular endothelial cells – inducible following injury.
We recommend
References
VE cadherin
Localized in junctions between endothelial cells and on HSCs and mesenchymal stem cells.
We recommend
References
View 1 reference for VE cadherin
VEGF-R2
Localized in endothelial cells, endothelial cell progenitor.
We recommend
References
von Willebrand Factor
Alternative names vWF
Localized in endothelial cells megakaryocytes.
We recommend
References
View 1 reference for von Willebrand Factor
References
CD31
Nourshargh, S. The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J. Leukoc. Biol. 80 ,714-718 (2006)
CD34
Sidney, L. E., Branch, M. J., Dunphy, S. E., et al. Concise review: Evidence for CD34 as a common marker for diverse progenitors. Stem cells 32 ,1380-1389 (2014)
CD45
Nakano, A., Harada, T., Morikawa, S. , & Kato, Y. Expression of leukocyte common antigen (CD45) on various human leukemia/lymphoma cell lines. Acta Pathol. Jpn. 40 ,107–115 (1990)
ICAM-1
Dustin, M. L., Rothlein, R., et al. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137 ,245–54 (1986)
LYVE-1
Jackson, D. G. The lymphatics revisited: New perspectives from the hyaluronan receptor LYVE-1. T rends in Cardiovascular Medicine 13 ,1-7 (2003)
Tie-2
Sato, T. N. , et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 376 ,70-74 (1995)
VCAM-1
Ulyanova, T. et al. VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. Blood 106 ,86–94 (2005)
VE cadherin
Vestweber, D. VE-cadherin: The major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arteriosclerosis, Thrombosis, and Vascular Biology 28 ,223–232 (2008)
VEGF-R2
Ferrara, N., Gerber, H. P. & , LeCouter J. The biology of VEGF and its receptors. Nat Med 9 ,669–676 (2003)
von Willebrand Factor
Sadler, J. E. Biochemistry and genetics of von Willebrand factor. Annu. Rev. Biochem. 67 ,395-424 (1998)