What are immature neurons and IPC?
Radial glia divides asymmetrically to produce one radial glial cell and one intermediate progenitor cell (IPC). IPCs differentiate into post-mitotic immature neurons, which migrate to their final destination in the nervous system and integrate into the neuronal network.
T-box brain protein 2
Alternative names Eomesodermin, TBR2
Gene name EOMES
A transcription factor whose expression marks the transition from radial glia to intermediate progenitors.
Embryonic (E15) mouse cortical sections stained with anti-TBR2 (red) (ab23345).
We recommend
TBR2 antibodies
References
View 4 references for T-box brain protein 2
MASH1
Alternative names Achaete-scute homolog 1, ASCL1
Gene name ASCL1
A transcription factor essential for neural differentiation. Please note that it can also label active neural stem cells.
Mouse subventricular zone tissue sections stained with anti-MASH1 (ab74065).
We recommend
MASH1 antibodies
References
View 5 references for MASH1
Doublecortin
Alternative names Doublin, lissencephalin-X
Gene name DCX
A microtubule-associated phosphoprotein that promotes neurite extension and cell migration.
Mouse adult dentate gyrus sections stained with anti-doublecortin (red) (ab18723).
We recommend
Doublecortin antibodies
References
View 4 references for Doublecortin
Beta III tubulin
Alternative names βIII-tubulin, β3-tubulin, β-tubulin III, Class III β-tubulin
Gene name TUBB3
A class of tubulin whose expression is limited to neurons and is used to label immature neurons.
Mouse embryonic spinal cord stained with anti-beta III tubulin (red) (ab78078).
We recommend
Beta III Tubulin antibodies
References
View 2 references for Beta III tubulin
NeuroD1
Alternative names Neurogenic differentiation 1
Gene name NEUROD1
A transcription factor that promotes neuronal development.
Mouse brain tissue stained with anti-neuroD1 (ab60704).
We recommend
NeuroD1 antibodies
References
View 4 references for NeuroD1
T-box brain protein 2
Gene name TBR1 , T-Brain 1 , TBR-1 , TES-56 , MGC141978
A transcription factor whose expression marks the transition from radial glia to intermediate progenitors.
Embryonic (E15) mouse cortical sections stained with anti-TBR2 (red) (ab23345).
We recommend
TBR1 antibodies
References
View 4 references for T-box brain protein 2
Stathmin 1
Alternative names Metablastin, oncoprotein 18
Gene name STMN1
A cytoplasmic phosphoprotein that is involved in cytoskeletal regulation.
Mouse brain tissue sections stained with anti-stathmin 1 (ab109986).
We recommend
Stathmin 1 antibodies
References
View 1 reference for Stathmin 1
References
T-box brain protein 2
Englund C,, Fink A,, Lau C,, et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex J Neurosci 25 (1),247-51 (2005)
Martí-Mengual U,, Varea E,, Crespo C,, et al. Cells expressing markers of immature neurons in the amygdala of adult humans Eur J Neurosci 37 (1),10-22 (2013)
Pollen AA,, Nowakowski TJ,, Chen J,, et al. Molecular identity of human outer radial glia during cortical development Cell 163 (1),55-67 (2015)
Shin J,, Berg DA,, Zhu Y,, et al. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell Cell Stem Cell 17 (3),360-72 (2015)
MASH1
Kim EJ,, Ables JL,, Dickel LK,, et al. Ascl1 (Mash1) defines cells with long-term neurogenic potential in subgranular and subventricular zones in adult mouse brain PLoS One 6 (3), (2011)
Kwak M,, Lim S,, Kang E,, et al. Effects of Neonatal Hypoxic-Ischemic Injury and Hypothermic Neuroprotection on Neural Progenitor Cells in the Mouse Hippocampus Dev Neurosci 37 (4-5),428-39 (2015)
Martí-Mengual U,, Varea E,, Crespo C,, et al. Cells expressing markers of immature neurons in the amygdala of adult humans Eur J Neurosci 37 (1),10-22 (2013)
Pollen AA,, Nowakowski TJ,, Chen J,, et al. Molecular identity of human outer radial glia during cortical development Cell 163 (1),55-67 (2015)
Shin J,, Berg DA,, Zhu Y,, et al. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell Cell Stem Cell 17 (3),360-72 (2015)
Doublecortin
Kwak M,, Lim S,, Kang E,, et al. Effects of Neonatal Hypoxic-Ischemic Injury and Hypothermic Neuroprotection on Neural Progenitor Cells in the Mouse Hippocampus Dev Neurosci 37 (4-5),428-39 (2015)
Martí-Mengual U,, Varea E,, Crespo C,, et al. Cells expressing markers of immature neurons in the amygdala of adult humans Eur J Neurosc i 37 (1),10-22 (2013)
Pollen AA,, Nowakowski TJ,, Chen J,, et al. Molecular identity of human outer radial glia during cortical development Cell 163 (1),55-67 (2015)
Shin J,, Berg DA,, Zhu Y,, et al. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell Cell Stem Cell 17 (3),360-72 (2015)
Beta III tubulin
Katsetos CD,, Karkavelas G,, Herman MM,, et al. Class III beta-tubulin isotype (beta III) in the adrenal medulla: I. Localization in the developing human adrenal medulla. Anat Rec Anat Rec 250 (3),335-43 (1998)
Menezes JR,, Luskin MB Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon J Neurosci 140 (9),5399-416 (1994)
NeuroD1
Kwak M,, Lim S,, Kang E,, et al. Effects of Neonatal Hypoxic-Ischemic Injury and Hypothermic Neuroprotection on Neural Progenitor Cells in the Mouse Hippocampus Dev Neurosci 37 (4-5),428-39 (2015)
Martí-Mengual U,, Varea E,, Crespo C,, et al. Cells expressing markers of immature neurons in the amygdala of adult humans Eur J Neurosci 37 (1),10-22 (2013)
Pollen AA,, Nowakowski TJ,, Chen J,, et al. Molecular identity of human outer radial glia during cortical development Cell 163 (1),55-67 (2015)
Shin J,, Berg DA,, Zhu Y,, et al. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell Cell Stem Cell 17 (3),360-72 (2015)
T-box brain protein 2
Englund C,, Fink A,, Lau C,, et al. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex J Neurosci 25 (1),247-51 (2005)
Martí-Mengual U,, Varea E,, Crespo C,, et al. Cells expressing markers of immature neurons in the amygdala of adult humans Eur J Neurosci 37 (1),10-22 (2013)
Pollen AA,, Nowakowski TJ,, Chen J,, et al. Molecular identity of human outer radial glia during cortical development Cell 163 (1),55-67 (2015)
Shin J,, Berg DA,, Zhu Y,, et al. Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis. Cell Stem Cell Cell Stem Cell 17 (3),360-72 (2015)
Stathmin 1
Rubin CI,, Atweh GF The role of stathmin in the regulation of the cell cycle J Cell Biochem 93 (2),242-50 (2004)
