Megakaryocytes are highly specialized precursor cells that function solely to produce and release platelets into the circulation.

Platelets play an important role in the regulation of homeostasis.

CD36

Alternative names Fatty acid translocase, Glycoprotein IIIb, GP3B, GP4, GPIV, PASIV, SCARB3

Facilitates tissue fatty acid uptake and oxidation. Involved in signal transduction in immunity and atherosclerosis. High affinity receptor for native lipoproteins HDL, LDL and VLDL.

We recommend

Anti-CD36 antibody [EPR22509-40] (ab252922)

CD41

Alternative names Integrin alpha-IIb, GPalpha IIb, ITGA2B, GP2B, GTA

Platelet activation and aggregation.

We recommend

Anti-CD41 antibody [M148] (ab11024)

Anti-CD41 antibody [HIP8] (ab15021)

CD42a

Alternative names Platelet glycoprotein IX, GP9

Platelet adhesion and aggregation. Amplifies platelet response to thrombin.

We recommend

APC Anti-CD42a/GP-IX antibody [GR-P] (ab270643)

CD42b

Alternative names Platelet glycoprotein Ib alpha chain, BSS, GP1B

Platelet adhesion and aggregation.

We recommend

APC Anti-CD42a/GP-IX antibody [GR-P] (ab183345)

Anti-CD42b antibody [AK2] (ab61402)

CD61

Alternative names Integrin beta-3, ITGB3, GP3A

Regulates extracellular signals and intracellular pathways. Plays a key role in embryonic development and sperm maturation.

We recommend

Anti-Integrin beta 3 antibody [VI-PL2] (ab110131)

Anti-Integrin beta 3 antibody [EPR2342] (ab119992)

Further reading

See the references below for a list of relevant reviews.

References

View 4 references for Further reading

References

Further reading

Chang, Y., Bluteau, D., Debili, N., Vainchenker, W. From hematopoietic stem cells to platelets  J. Thromb. Haemost.  5 ,318-327 (2007)

Novershtern, N., et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis Cell  144 ,296-309 (2011)

Deutsch, V. R., Tomer, A. Megakaryocyte development and platelet production  Br. J. Haematol.   134 ,453-466 (2006)

Van Velzen, J. F., Laros-Van Gorkom, B. A. P., Pop, G. A. M., Van Heerde, W. L. Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers  Thromb. Res.   130 ,92-98 (2012)