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Schwann cell markers

A guide to Schwann cell markers throughout development. Here we review the most common markers for different Schwann cell stages throughout the development, so you can quickly choose the right marker

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Last edited Fri 26 Apr 2024

What are Schwann cells?

Schwann cells are the myelin-producing cells of the peripheral nervous system, where they form the myelin sheath around axons. Their function is equivalent to that of oligodendrocytes in the central nervous system.

Myelin protein zero

Alternative names:

P0, MPZ

Gene names:

MPZ

A structural component of the myelin sheath.

Rat Schwann cells stained with anti-myelin protein zero (ab31851).

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NCAM

Alternative names:

Neural cell adhesion molecule, CD56

Gene names:

NCAM1

A glycoprotein involved in cell adhesion, expressed by non-myelinating Schwann cells.

Zebrafish embryo stained with anti-NCAM (green) (ab9272).

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GAP43

Alternative names:

Growth Associated Protein 43

Gene names:

GAP43

A cytoplasmic protein expressed by non-myelinating glia.

Rat spinal cord (ventral horn) stained with GAP43 (ab16053).

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S100

Gene names:

S100

Homodimeric protein that is often found in cells derived from the neural crest.

Rat Schwann cells stained with anti-S100 (ab4066).

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p75NTR

Alternative names:

p75 neurotrophin receptor, low-affinity nerve growth factor receptor, LNGFR

The p75 NGF receptor (also known as p75 neurotrophin receptor or p75NTR) binds nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), as well as neurotrophins 3 and 4. 

PC12 cells stained with anti-p75 NGF antibody (ab52987).

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