Serotonergic neurons synthesize the neurotransmitter serotonin (5-HT), which is found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS).
We've put together several well-characterized serotonergic neuron markers to help you identify your neuronal population.
Tryptophan hydroxylase
Alternative names (TPH)
Gene name TPH1
Tryptophan hydroxylase (TPH) is an enzyme involved in serotonin synthesis. There are two isoforms: TPH1 and TPH2. TPH2 is the isoform predominantly found in the brain.
Mouse dorsal raphe coronal brain slices stained with anti-TPH2 (ab111828).
We recommend
TPH2 antibodies
TPH2 proteins and peptides
References
View 6 references for Tryptophan hydroxylase
Serotonin transporter
Alternative names (SERT)
Gene name SLC6A4
A transmembrane protein that is responsible for the re-uptake of 5-HT from the synaptic cleft into the presynaptic neuron.
Serotonin transporter inhibitors
Human cerebral cortex stained with anti-serotonin transporter (ab174770).
We recommend
Serotonin transporter antibodies
Serotonin transporter proteins and peptides
References
View 5 references for Serotonin transporter
Pet1
A transcription factor that drives the transcription of genes essential for the metabolism as well as re-uptake of serotonin.
We recommend
References
Tryptophan hydroxylase
Deecher DC,, Beyer CE,, Johnston G,, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor J Pharmacol Exp Ther 318 (2),657-65 (2006)
Hendricks TJ,, Fyodorov DV,, Wegman LJ,, et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior Neuron 37 (2),233-47 (2003)
Kittler K,, Lau T,, Schloss P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons Eur J Pharmacol 629 (1-3),63-7 (2010)
Liu C,, Maejima T,, Wyler SC,, et al. Pet-1 is required across different stages of life to regulate serotonergic function Nat Neurosci 13 (10),1190-8 (2010)
Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential Drugs Future 29 (12),1235-1244 (2004)
Serotonin transporter
Deecher DC,, Beyer CE,, Johnston G,, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor J Pharmacol Exp Ther 318 (2),657-65 (2006)
Hendricks TJ,, Fyodorov DV,, Wegman LJ,, et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior Neuron 37 (2),233-47 (2003)
Kittler K,, Lau T,, Schloss P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons Eur J Pharmacol 629 (1-3),63-7 (2010)
Liu C,, Maejima T,, Wyler SC,, et al. Pet-1 is required across different stages of life to regulate serotonergic function Nat Neurosci 13 (10),1190-8 (2010)
Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential Drugs Future 29 (12),1235-1244 (2004)
