Serotonergic neuron markers

Your guide to selecting serotonergic neuron markers.

Serotonergic neurons synthesize the neurotransmitter serotonin (5-HT), which is found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS).

We've put together several well-characterized serotonergic neuron markers to help you identify your neuronal population.

Tryptophan hydroxylase

Alternative names (TPH)

Gene name TPH1

Tryptophan hydroxylase (TPH) is an enzyme involved in serotonin synthesis. There are two isoforms: TPH1 and TPH2. TPH2 is the isoform predominantly found in the brain.

Mouse dorsal raphe coronal brain slices stained with anti-TPH2 (ab111828).

Mouse dorsal raphe coronal brain slices stained with anti-TPH2 (ab111828).

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TPH2 antibodies

TPH2 proteins and peptides

References

View 6 references for Tryptophan hydroxylase

Serotonin transporter

Alternative names (SERT)

Gene name SLC6A4

A transmembrane protein that is responsible for the re-uptake of 5-HT from the synaptic cleft into the presynaptic neuron.​

Serotonin transporter inhibitors

Product
Activity
Nisoxetine hydrochloride (ab141134)
Potent SERT and NET inhibitor
Venlafaxine hydrochloride (ab120715)
Selective NET/SERT i

Human cerebral cortex stained with anti-serotonin transporter (ab174770).

Human cerebral cortex stained with anti-serotonin transporter (ab174770).

We recommend

Serotonin transporter antibodies

Serotonin transporter proteins and peptides

References

View 5 references for Serotonin transporter

Pet1

A transcription factor that drives the transcription of genes essential for the metabolism as well as re-uptake of serotonin.

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References

Tryptophan hydroxylase

Deecher DC,, Beyer CE,, Johnston G,, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor J Pharmacol Exp Ther 318 (2),657-65 (2006)

Hendricks TJ,, Fyodorov DV,, Wegman LJ,, et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior Neuron 37 (2),233-47 (2003)

Kittler K,, Lau T,, Schloss P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons Eur J Pharmacol 629 (1-3),63-7 (2010)

Liu C,, Maejima T,, Wyler SC,, et al. Pet-1 is required across different stages of life to regulate serotonergic function Nat Neurosci 13 (10),1190-8 (2010)

Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential Drugs Future 29 (12),1235-1244 (2004)

Serotonin transporter

Deecher DC,, Beyer CE,, Johnston G,, et al. Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor J Pharmacol Exp Ther 318 (2),657-65 (2006)

Hendricks TJ,, Fyodorov DV,, Wegman LJ,, et al. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior Neuron 37 (2),233-47 (2003)

Kittler K,, Lau T,, Schloss P. Antagonists and substrates differentially regulate serotonin transporter cell surface expression in serotonergic neurons Eur J Pharmacol 629 (1-3),63-7 (2010)

Liu C,, Maejima T,, Wyler SC,, et al. Pet-1 is required across different stages of life to regulate serotonergic function Nat Neurosci 13 (10),1190-8 (2010)

Zhou J. Norepinephrine transporter inhibitors and their therapeutic potential Drugs Future 29 (12),1235-1244 (2004)