Anti-Endostatin/COL18A1 antibody [KT60] (HRP) (ab106491)

Overview

  • Product name

    Anti-Endostatin/COL18A1 antibody [KT60] (HRP)
    See all Endostatin/COL18A1 primary antibodies
  • Description

    Mouse monoclonal [KT60] to Endostatin/COL18A1 (HRP)
  • Host species

    Mouse
  • Conjugation

    HRP
  • Tested applications

    Suitable for: Sandwich ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human Endostatin/COL18A1 (N terminal).

  • General notes

     This product was previously labelled as Endostatin

     

Properties

Applications

Our Abpromise guarantee covers the use of ab106491 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA 1/1000. Can be paired for Sandwich ELISA with Mouse monoclonal [KT58] to Endostatin/COL18A1 (ab114141).

Target

  • Function

    COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.
    Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
  • Tissue specificity

    Present in multiple organs with highest levels in liver, lung and kidney.
  • Involvement in disease

    Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.
  • Sequence similarities

    Belongs to the multiplexin collagen family.
    Contains 1 FZ (frizzled) domain.
    Contains 1 TSP N-terminal (TSPN) domain.
  • Post-translational
    modifications

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • Alpha 1 collagen type 18 (XVIII)(COL18A1) antibody
    • Alpha 1 type XVIII collagen antibody
    • Antiangiogenic agent antibody
    • COIA1_HUMAN antibody
    • COL15A1 antibody
    • Col18a1 antibody
    • Collagen alpha 1(XV) chain antibody
    • Collagen alpha 1(XVIII) chain antibody
    • Collagen alpha-1(XV) chain antibody
    • Collagen type XV proteoglycan antibody
    • Collagen type XVIII alpha 1 antibody
    • Collagen XV, alpha 1 polypeptide antibody
    • Collagen, type XV, alpha 1 antibody
    • Endostatin antibody
    • Endostatin XV antibody
    • FLJ27325 antibody
    • FLJ34914 antibody
    • FLJ38566 antibody
    • KNO antibody
    • KNO1 antibody
    • KS antibody
    • MGC74745 antibody
    • Multi functional protein MFP antibody
    • OTTHUMP00000021782 antibody
    • OTTHUMP00000115472 antibody
    • OTTHUMP00000115473 antibody
    see all

Images

  • ab106491 at 1/1000 dilution detecting Endostatin/COL18A1 by sandwich ELISA. The capture antibody is a mouse monclonal (IgG1) raised against Human Endostatin/COL18A1.

References

ab106491 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer

I am very sorry for the delayed answer. I can now confirm that ab106491 has been tested and is guaranteed to work with ab114141 as an sandwich ELISA pair. The datasheet for ab114141 can be found following this link: Click here (or use the following: https://www.abcam.com/index.html?datasheet=114141). I hope this information was helpful. Please do not hesitate to contact me again with any further questions.

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